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Find out how your medicine works, how and when to take it, possible side effects and answers to your common questions. Consumption of grapefruit juice should be avoided while taking losartan tablets. The use of losartan is not recommended during the first trimester of Grapefruit juice may potentially reduce the effectiveness of tamoxifen. [83] Trazodone (Desyrel): Little or no interaction with grapefruit juice. [84] Verapamil (Calan SR, Covera HS, Isoptin SR, Verelan): atrioventricular conduction disorders. [61] Warfarin (coumadin) [85] Zolpidem (Ambien): Little or no interaction with grapefruit juice [84] kaitlib fe images Combining Losartan with certain foods, herbs, or alcohol can trigger side-effects and alter the drug’s efficacy. Grapefruit Juice: Interaction of grapefruit juice with losartan decreases the Grapefruit juice (GJ), a cytochrome P450 (CYP) 3A4 inhibitor, may affect the pharmacokinetics of drugs metabolized through CYP 3A4. Losartan, an angiotensin II antagonist, is converted into its main active metabolite E3174 by CYP 3A4 and CYP 2C9. The effect of GJ on losartan pharmacokinetics was assessed in a randomized crossover trial. 1. Introduction. The first grapefruit juice (GFJ)-drug interaction was serendipitously identified by Bailey and colleagues in 2024 [].As a result of extensive work conducted since this initial discovery, the scientific literature is now replete with information regarding the effects of GFJ and its constituents on drug disposition, both in vitro and in vivo [2-6].
The liver activates losartan to make it work. Grapefruit juice might decrease how quickly the body activates losartan. Drinking grapefruit juice while taking losartan might decrease the effects of losartan. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) Some medications are changed and broken down by the liver.
each tablet contains: calcium 15 mg store between C ( F). Protect from light. DIPHENHYDRAMINE HYDROCHLORIDE: 25 mg: Inactive Ingredients: Ingredient gabapentin for neuropathy Diphenhydramine pills are typically 25 mg each, but there are smaller 12.5 mg tablets and larger 50 mg tablets. You can adjust the tablet dosage in the calculator below to help you determine how many tablets to give within their dosage range. It gets trickier for cats weighing much less than 12.5 pounds or much more than 12.5 pounds (unless your cat is quite large a 25- pound cat can take a full 25 mg tablet of Benadryl). Liquid Benadryl for cats might be easier to measure and also easier to give to a cat (cats are notoriously difficult to get to swallow pills).